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Histone H1-DNA interactions and their relation to chromatin structure and function.

J Zlatanova·J Yaneva
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Abstract

The belief that histone H1 interacts primarily with DNA in chromatin and much less with the protein component has led to numerous studies of artificial H1-DNA complexes. This review summarizes and discusses the data on different aspects of the interaction between the linker histone and naked DNA, including cooperativity of binding, preference for supercoiled DNA, selectivity with respect to base composition and nucleotide sequence, and effect of H1 binding on the conformation of the underlying DNA. The nature of the interaction, the structure of the complexes, and the role histone H1 exerts in chromatin are also discussed.

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ChromatinDNADNA, SuperhelicalHistonesNucleic Acid ConformationJournal ArticleReview

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J Zlatanova, J Yaneva. 1991. Histone H1-DNA interactions and their relation to chromatin structure and function.. https://doi.org/10.1089/dna.1991.10.239

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