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PubMed · 2030105

Beyond serotonin.

H Y Meltzer
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Abstract

Available therapies for treating depression, even the specific serotonin reuptake blockers, may not act via a serotonergic mechanism. Regardless of the mechanism of action, limitations in efficacy, onset of action, and side effects of all available antidepressant drugs indicate the need for further efforts to develop superior treatments of depression. A number of novel approaches are currently being investigated, including beta-adrenergic agonists, alpha-adrenergic antagonists, tetrahydrobiopterin, GABAergic drugs and non-pharmacologic therapies such as light therapy. These treatments may act independently of serotonin, yet there are intriguing suggestions that even their action is linked to serotonin.

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Adenylate KinaseAntidepressive AgentsBiopterinsDepressive DisorderHumansPhototherapyProtein KinasesReceptors, SerotoninSerotoningamma-Aminobutyric AcidJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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H Y Meltzer. 1991. Beyond serotonin.. https://pubmed.ncbi.nlm.nih.gov/2030105/

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