PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 2043450

Behçet's disease.

Y Mizushima
View original source ↗Export metadata ↓

Abstract

Recent studies have revealed the important role of streptococci in the etiology of Behçet's disease. Among patients with Behçet's disease, there is a high incidence of a history of streptococcal infections. Certain antigens of streptococci induced not only cutaneous, delayed-type hypersensitivity, but also systemic attacks of Behçet's disease when skin tests were performed. Neutrophil-activating lymphokines are produced when streptococcal antigen reacted with lymphocytes from patients with Behçet's disease. The first international diagnostic criteria for Behçet's disease were prepared by multicenter studies and published recently. With recent progress in diagnostic imaging techniques, magnetic resonance imaging and position emission tomography are particularly important for the diagnosis of neuro-Behçet's disease. In Japan, cyclosporin was also proved to be effective for eye lesions of Behçet's disease in a double-blind clinical trial comparing this drug with colchicine.

Explore related subjects

Behcet SyndromeCyclosporinsHumansStreptococcal InfectionsJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Y Mizushima. 1991. Behçet's disease.. https://pubmed.ncbi.nlm.nih.gov/2043450/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2024

Omics studies in Behçet's disease.

PURPOSE OF REVIEW: In this review, we aimed to highlight recent findings from "-omics" studies in Behçet's disease. RECENT FINDINGS: Recent genomic studies in Behçet's disease identified possible risk loci associated with Behçet's disease related uveitis, neurologic involvement and gastrointestinal involvement. Additionally, sex-specific genetic effects were determined in Behçet's disease. Transcriptomic analyses of immune cells in Behçet's disease revealed that key inflammatory pathways such as NF-κB and MAPK have roles in Behçet's disease pathogenesis. Proteomic studies have highlighted the role of immune cell derived extracellular vesicles and identified potential biomarkers for vascular involvement and examined HLA I-bound immunopeptidomes. Metabolomics studies are still limited, but recent research has pointed to alterations in fatty acid metabolism and lipid profiles in Behçet's disease patient. SUMMARY: Omics studies have gained importance in the field of Behçet's disease through the generation of large data sets and efforts to extend their application are intensifying. These studies can provide opportunities for understanding Behçet's disease pathogenesis when they lead to testable hypotheses. Current challenges include the choice of appropriately homogeneous patient and control groups, effective data management and sharing, high cost and a rapidly increasing gap between the wealth of observational data generated and the relative paucity of controlled experimental efforts that could lead to mechanistic understanding.

Behcet Syndrome↗
PubMed2006

[Behçet disease].

Explore the source record for details and available documents.

Behcet Syndrome↗