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PubMed · 2047758

Natural killer function in the rat with interstitial nephritis.

T Bricio·F Mampaso
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Abstract

Brown Norway (BN) rats with tubulointerstitial nephritis (TIN) have an augmented NK activity. Immunological manifestations of the disease indicate the existence of a highly activated B-cell system, as reflected in the high levels of circulating antibodies and in the predominant spontaneous IgG-producing B-cells in cultures. In addition, NK cells appear to induce positive signals for antibody production either when co-cultured with B-cells alone or after treatment with poly I:C. Our results suggest that NK cells might play a role in the immunoregulation of the humoral response in this disease.

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AnimalsB-LymphocytesCells, CulturedCyclosporinsCytotoxicity Tests, ImmunologicEnzyme-Linked Immunosorbent AssayImmunoglobulin GKiller Cells, NaturalLymphocyte ActivationMaleNephritis, InterstitialPoly I-CRatsRats, Inbred BNSpleenJournal ArticleResearch Support, Non-U.S. Gov't

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T Bricio, F Mampaso. 1991. Natural killer function in the rat with interstitial nephritis.. https://doi.org/10.1111/j.1365-3083.1991.tb02536.x

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