Chemoattractants produced by ocular cells induce trabecular meshwork cell migration.

C M Calthorpe; I Grierson; R A Hitchings

doi:10.1007/bf00153926

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Chemoattractants produced by ocular cells induce trabecular meshwork cell migration.

C M Calthorpe·I Grierson·R A Hitchings

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Abstract

Media conditioned by bovine corneal endothelium and scleral fibroblasts were found to induce the migration of bovine trabecular meshwork cells. The migrational activity had both chemokinetic (stimulated random motion) and chemotactic (directional migration) components. That produced by corneal endothelial cells had a markedly more potent effect. The relevance of these in vitro studies is discussed. Biochemically stimulated migration and loss of meshwork cells may be involved in the pathogenesis of glaucoma.

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Animals Cattle Cell Movement Cells, Cultured Chemotactic Factors Endothelium, Corneal Fibroblasts Sclera Trabecular Meshwork Journal Article Research Support, Non-U.S. Gov't

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C M Calthorpe, I Grierson, R A Hitchings. 1991. Chemoattractants produced by ocular cells induce trabecular meshwork cell migration.. https://doi.org/10.1007/bf00153926

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