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PubMed · 2053769

[BCL-2 gene in lymphocytic malignancy].

M Seto·K Yamamoto·H Osada·R Ueda
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Abstract

In t(14;18) (q32;q21) lymphomas, bcl-2 gene is activated by the juxtaposition of immunoglobulin (Ig) gene. The fused bcl-2-Ig gene generates chimeric mRNAs which consist of bcl-2 at 5' portion and Ig at 3' portion. Chimeric mRNA does not disrupt the bcl-2 coding frame of 239 amino acid polypeptide. Bcl-2-Ig transgenic mice demonstrated the extended B cell survival and the follicular lymphoproliferation, but they did not develop a malignancy until 25 weeks. Ten percent of them, however, developed malignant diffuse large-cell lymphomas after a long latency. Forty percent of these malignancies demonstrated the c-myc rearrangement, indicating that multiple step changes are required for malignant transformation in bcl-2 activated cells. Study on the bcl-2 gene rearrangement in Japanese B cell lymphoma and B-CLL revealed that 10 out of 32 cases of follicular lymphoma (31%), 5 out of 56 cases of diffuse lymphoma (9%) and 2 out of 30 cases of B-CLL (7%) were rearranged. Less frequency of B cell lymphoma, particularly follicular lymphoma in Japan might be partly due to the less bcl-2 involvement than in American cases. The ratio of bcl-2 involvement in B-CLL is not significantly different between Japan and U.S.A.. bcl-2 rearrangement at 5' promoter region is noted for Japanese B-CLL which was demonstrated for American cases. The clinical application of polymerase chain reaction for bcl-2 translocation was also discussed.

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AnimalsGene RearrangementGene Rearrangement, B-LymphocyteGene Rearrangement, B-Lymphocyte, Heavy ChainGenes, ImmunoglobulinHumansLymphoma, B-CellLymphoma, FollicularMiceMice, TransgenicOncogenesTranslocation, GeneticEnglish AbstractJournal ArticleReview

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M Seto, K Yamamoto, H Osada, R Ueda. 1991. [BCL-2 gene in lymphocytic malignancy].. https://pubmed.ncbi.nlm.nih.gov/2053769/

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