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PubMed · 2071141

Aland eye disease: linkage data.

M Schwartz·T Rosenberg
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Abstract

A large Danish family with Aland Island eye disease (AIED) was studied by linkage analysis using 16 polymorphic DNA markers covering the whole X chromosome. Positive lod scores were found for marker loci at the proximal part of the short arm of the X chromosome, DXS255 and TIMP (Zmax = 3.93 and 3.18 at theta = 0.0), suggesting an assignment of the locus for AIED to this part of the X chromosome. Recombination was observed with the locus DXS7 as well as with other loci distal to DXS7. These results are not in agreement with the deletion presented previously by D-A. M. Pillers et al. (1990, Am. J. Med. Genet. 36: 23-28), which mapped AIED to Xp21.

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DNA ProbesEye DiseasesFemaleGenetic LinkageHumansLod ScoreMaleNight BlindnessPedigreePolymorphism, GeneticSyndromeX ChromosomeJournal ArticleResearch Support, Non-U.S. Gov't

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M Schwartz, T Rosenberg. 1991. Aland eye disease: linkage data.. https://doi.org/10.1016/0888-7543(91)90315-6

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