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PubMed · 2103610

[Chronic candidosis].

Abstract

The paper deals with the problem of mucocutaneous candidosis, because the incidence of the disease is increasing steadily in recent years. The author draws attention to various already known causes of the development of candidosis and submits also some hypothese reported in the literature. The classification of candidosis should facilitate diagnostic work of the attending physician. In therapy in particularly refractory candidoses are emphasized and the author present on the example of one patient an account of recent therapeutic possibilities.

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BibTeXRIS

S Zábrodský. 1990. [Chronic candidosis].. https://pubmed.ncbi.nlm.nih.gov/2103610/

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Chemokine receptor expression in HIV-positive persons with oropharyngeal candidiasis.

OBJECTIVE: In HIV+ persons with reduced CD4+ T cells, oropharyngeal candidiasis (OPC) is often associated with the accumulation of CD8+ T cells at the epithelial/lamina propria interface within the lesion together with increased tissue-associated cytokines and chemokines. Despite this reactivity, a dysfunction in the ability of the CD8+ cells to reach the organism at the outer epithelium is postulated. The purpose of this study was to examine chemokine receptors present in the OPC lesions for a potential role in susceptibility to infection. METHODS: Biopsies taken from buccal mucosa of HIV- persons, healthy mucosa of HIV+ OPC- persons, and OPC lesions were processed for protein immunohistochemical staining or RNA analysis by real-time PCR and Superarray. RESULTS: There was little change in expression of chemokine receptors at the protein or RNA level between OPC+ and OPC- tissue. At the protein level, increases occurred in OPC+ persons only if associated with CD8 cells. In the Superarray, of the 22 chemokine receptor mRNAs expressed, c. 90% remained unchanged (< 1.0-fold change) between HIV- and HIV+ tissue and between HIV+ OPC- and HIV+ OPC+ tissue. CONCLUSION: Tissue-associated chemokine receptor expression does not appear to contribute to the dysfunction in cellular migration associated with susceptibility to OPC.

Candidiasis, Oral↗