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Genetic studies on human thyroxine-binding globulin (TBG).

C Luckenbach·J Kömpf·H Ritter
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Abstract

An enzyme immunoassay technique combined with Western blotting is described to demonstrate thyroxine-binding globulin (TBG) by isoelectric focusing in thin-layer polyacrylamide gels with 8 mol/l urea. Quantitative evaluation was by laser densitometry. No genetic charge variants of TBG were encountered in a sample of 840 unrelated individuals from southwestern Germany. There was no correlation between structural and quantitative variations in the TBG protein. Results from a family with quantitative TBG deficiency strongly support the postulated X-linked mode of inheritance. The method described can be considered as an additional diagnostic tool in thyroid evaluation.

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Electrophoresis, Polyacrylamide GelFemaleHumansIsoelectric FocusingMalePedigreePhenotypeThyroxine-Binding ProteinsJournal Article

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BibTeXRIS

C Luckenbach, J Kömpf, H Ritter. 1990. Genetic studies on human thyroxine-binding globulin (TBG).. https://doi.org/10.1007/bf00196237

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