Neuron-specific and state-specific differences in calcium homeostasis regulate the generation and degeneration of neuronal architecture.

L R Mills; S B Kater

doi:10.1016/0896-6273(90)90451-k

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Neuron-specific and state-specific differences in calcium homeostasis regulate the generation and degeneration of neuronal architecture.

L R Mills·S B Kater

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Abstract

Many stimuli (e.g., neurotransmitters and electrical activity) regulate neuromorphogenesis by changing intracellular calcium. The ionophore A23187 was employed as a receptor-independent method to investigate neuronal calcium homeostasis. Distinctive neuron-specific (B5 versus B19) and state-specific (growing versus non-growing) differences in calcium homeostasis were observed in cultured identified Helisoma neurons. Fura-2 studies revealed that A23187 induced a transient rise in intracellular calcium in growing neurons B5 but a sustained rise in growing neurons B19. In stable-state (non-growing) cells A23187 evoked only a transient calcium rise. Both neuron-specific and state-specific differences in calcium homeostasis were dependent on extracellular sodium. Morphological studies also indicated that such differences in calcium-regulatory capacity can have profound consequences on the generation and degeneration of neuronal architecture.

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Animals Axons Calcimycin Calcium Cell Survival Cells, Cultured Homeostasis Neurons Snails Sodium Journal Article Research Support, U.S. Gov't, P.H.S.

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L R Mills, S B Kater. 1990. Neuron-specific and state-specific differences in calcium homeostasis regulate the generation and degeneration of neuronal architecture.. https://doi.org/10.1016/0896-6273(90)90451-k

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