[Decrease of the contraction force of skeletal muscle in mammals by the potassium channel activator, SR 44866].

I Findlay; M P Sauviat

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PubMed · 2114192

[Decrease of the contraction force of skeletal muscle in mammals by the potassium channel activator, SR 44866].

I Findlay·M P Sauviat

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Abstract

The ATP-sensitive K channel opener, SR 44866, was applied to intact extensor digitorum muscle of the mouse. Electrically stimulated maximal twitch contractions of the muscle were decreased by SR 44866 with a KD of 7.4 microM and a Hill coefficient of 1.2 at 34 degrees C. The effect of SR 44866 was antagonized by glibenclamide and reduced at 24 degrees C. We suggest that these results represent the consequence of activation of ATP-sensitive K channels in mammalian skeletal muscle.

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Adenosine Triphosphate Animals Benzopyrans Binding Sites Binding, Competitive Depression, Chemical Dihydropyridines Dose-Response Relationship, Drug Male Mammals Mice Muscle Contraction Potassium Channels Temperature English Abstract Journal Article Research Support, Non-U.S. Gov't

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I Findlay, M P Sauviat. 1990. [Decrease of the contraction force of skeletal muscle in mammals by the potassium channel activator, SR 44866].. https://pubmed.ncbi.nlm.nih.gov/2114192/

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