Does Mycobacterium tuberculosis have plasmids?

Z F Zainuddin; J W Dale

doi:10.1016/0041-3879(90)90060-l

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Does Mycobacterium tuberculosis have plasmids?

Z F Zainuddin·J W Dale

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Abstract

Evidence of the presence of plasmids in Mycobacterium tuberculosis is lacking, whereas they are widespread in some other mycobacterial species. We examined, by agarose gel electrophoresis, a total of 197 clinical isolates of M. tuberculosis, mostly resistant to one or more antibiotics, and were able to detect bands of apparently extrachromosomal DNA at a low level in some isolates. These presumptive plasmids could not be isolated by CsCl/ethidium bromide gradient ultracentrifugation, and may consist of unusual forms of DNA. The possible existence of single stranded plasmid DNA is discussed.

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Antitubercular Agents DNA, Bacterial Drug Resistance, Microbial Electrophoresis, Agar Gel Mycobacterium tuberculosis Plasmids Journal Article

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Z F Zainuddin, J W Dale. 1990. Does Mycobacterium tuberculosis have plasmids?. https://doi.org/10.1016/0041-3879(90)90060-l

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