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PubMed · 2115967

Aspirin--relieved asthma.

P R Garin·A Frans
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Abstract

It is widely known that there might occur three different responses to the administration of ASA or NSAID to patients with bronchial asthma-bronchoconstriction, bronchodilatation or lack of bronchopulmonary action. Nevertheless, the beneficial effect of SAID has been confirmed in patients who are both nonallergic and cortico-dependent asthmatics. Our hypothesis is that in these specific cases the arachidonic acid metabolism is diverted towards cyclo-oxygenase products and that this metabolic diversion leads to an increased production of bronchoconstriction prostaglandins. The administration of NSAID inhibits the cyclo-oxygenase suppressing the enhanced basal production of these bronchoconstrictors and relieving the bronchospasm. The suspected abnormality in arachidonic acid metabolism would be restricted to the respiratory system.

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Arachidonic AcidArachidonic AcidsAspirinAsthmaDrug ToleranceHumansModels, BiologicalProstaglandin-Endoperoxide SynthasesProstaglandinsComparative StudyJournal Article

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P R Garin, A Frans. 1990. Aspirin--relieved asthma.. https://doi.org/10.1016/0306-9877(90)90035-d

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