Two phosphorylation sites on eIF-2 alpha.

G Kramer

doi:10.1016/0014-5793(90)80919-a

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Two phosphorylation sites on eIF-2 alpha.

G Kramer

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Abstract

Protein synthesis in mammalian cells can be regulated through phosphorylation/dephosphorylation of the alpha subunit of initiation factor 2, eIF-2. Two specific kinases have been identified that apparently phosphorylate the same site(s). Controversy exists as to whether serine-48 is a phosphorylation site in addition to serine-51. A recent publication is discussed that, in this author's view, answers the question of the phosphorylation sites. It is suggested that phosphorylation proceeds sequentially with serine-51 being the first and serine-48 the second phosphorylation site. Phosphorylation of both sites is required for inhibition of protein synthesis.

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Binding Sites Eukaryotic Initiation Factor-2 Humans Mutation Phosphorylation Protein Biosynthesis Serine Journal Article Research Support, Non-U.S. Gov't

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G Kramer. 1990-07-16. Two phosphorylation sites on eIF-2 alpha.. https://doi.org/10.1016/0014-5793(90)80919-a

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