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The elephant man. Part III.

G R Seward
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Abstract

This is the third paper in a series of three articles on Joseph Merrick, The Elephant Man. Three matters are discussed about which there is uncertainty: the disease which affected his left femoral head, the cause of his deformity and the cause of his death.

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Fibrous Dysplasia of BoneHip JointHistory, 19th CenturyHumansMaleNeurofibromatosis 1Tuberculosis, OsteoarticularBiographyHistorical ArticleJournal Article

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G R Seward. 1990-10-20. The elephant man. Part III.. https://doi.org/10.1038/sj.bdj.4807332

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Congenital osteofibrous dysplasia associated with pseudoarthrosis of the tibia and fibula.

The association between congenital pseudoarthrosis and osteofibrous dysplasia of the tibia and fibula is a rare entity that has been recently recognized. We report a male newborn who was found to have swelling and deformity of the left lower leg. Radiographs and magnetic resonance imaging showed an extensive destructive lesion of the tibial shaft, with dysplastic congenital pseudoarthrosis of the lower fibula. Histopathological examination confirmed the diagnosis of congenital pseudoarthrosis of the tibia and fibula with underlying osteofibrous dysplasia involving both bones. Immunohistochemical stains showed cytokeratin positivity.

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