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PubMed · 2129427

Fos and jun: two into one will go.

J R Woodgett
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Abstract

c-jun was the first oncogene to be identified as a transcription factor thus realizing the long-standing prediction that gene regulation plays a fundamental role in growth control. Not so predictable was that this protein is assisted in its function by a second proto-oncogene, c-fos; that the transcription factor they help comprise transducers hormonal signals; and that each are the archetypal members of gene families. Here, I describe the remarkable progress that has been made from the initial characterization of these oncogenes to our current understanding of their normal cellular function.

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AnimalsDNA-Binding ProteinsHumansProto-Oncogene MasProto-Oncogene ProteinsProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-junProto-OncogenesTranscription FactorsJournal ArticleReview

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J R Woodgett. 1990. Fos and jun: two into one will go.. https://pubmed.ncbi.nlm.nih.gov/2129427/

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