Molecular mechanisms for lineage commitment in T cell development.

E A Robey; B J Fowlkes; D M Pardoll

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PubMed · 2129899

Molecular mechanisms for lineage commitment in T cell development.

E A Robey·B J Fowlkes·D M Pardoll

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Abstract

Thymocyte development is characterized by the ordered expression of T cell receptors as well as the accessory molecules, CD4 and CD8. Interactions of these critical surface molecules with MHC ligands expressed on thymic stromal cells mediate additional developmental processes. Now that the stages of thymic differentiation have been delineated, current investigations are addressing the mechanisms that underlie T cell lineage commitment and selection.

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Animals CD4 Antigens CD8 Antigens Chromosome Mapping Gene Rearrangement, T-Lymphocyte Lymphocyte Activation Mice Receptors, Antigen, T-Cell T-Lymphocytes Thymus Gland Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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E A Robey, B J Fowlkes, D M Pardoll. 1990. Molecular mechanisms for lineage commitment in T cell development.. https://pubmed.ncbi.nlm.nih.gov/2129899/

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