Enhanced affective aggression in genetically bred hypercholinergic rats.

O Pucilowski; B Eichelman; D H Overstreet; A H Rezvani; D S Janowsky

doi:10.1159/000119040

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Enhanced affective aggression in genetically bred hypercholinergic rats.

O Pucilowski·B Eichelman·D H Overstreet·A H Rezvani·D S Janowsky

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Abstract

Affective aggression was studied in pairs of Flinders Sensitive Line hypercholinergic rats (FSL) and Flinders Resistant Line (FRL) rats in shock-induced and apomorphine-induced fighting tests. FSL rats were significantly more aggressive in both tests. They had higher pain threshold, assessed by the jump-flinch method, than FRL rats. It is concluded that genetically developed cholinergic system supersensitivity has resulted in enhanced responsiveness to stimuli eliciting affective aggression.

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Acetylcholine Aggression Animals Apomorphine Depression Electroshock Male Pain Rats Reaction Time Sensory Thresholds Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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O Pucilowski, B Eichelman, D H Overstreet, A H Rezvani, D S Janowsky. Enhanced affective aggression in genetically bred hypercholinergic rats.. https://doi.org/10.1159/000119040

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