Overview: phosphorylation and translation control.

J W Hershey

doi:10.1159/000468744

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PubMed · 2133649

Overview: phosphorylation and translation control.

J W Hershey

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Abstract

Protein synthesis is controlled by the phosphorylation of proteins comprising the translational apparatus. At least 12 initiation factor polypeptides, 3 elongation factors and a ribosomal protein are implicated. Stimulation of translation correlates with enhanced phosphorylation of eIF-4F, eIF-4B, eIF-2B, eIF-3 and ribosomal protein S6, whereas inhibition correlates with phosphorylation of eEF-2 and the alpha-subunit of eIF-2. Strong evidence for regulatory roles exists for eIF-2, eIF-4F and eEF-2, whereas changes in other factor activities due to phosphorylation remain to be demonstrated. Regulation of the specific activity of the translational apparatus by phosphorylation appears to be a general mechanism for the control of rates of global protein synthesis, and may also play a role in modulating the translation of specific mRNAs.

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Amino Acid Sequence Cell Division Gene Expression Regulation Molecular Sequence Data Peptide Chain Elongation, Translational Peptide Chain Initiation, Translational Peptide Elongation Factors Peptide Initiation Factors Phosphorylation Protein Biosynthesis Ribosomal Proteins Journal Article Research Support, U.S. Gov't, P.H.S.Review

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J W Hershey. 1990. Overview: phosphorylation and translation control.. https://doi.org/10.1159/000468744

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