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Chemoreception by a cell with age-dependent receptor binding sites.

B J Geurts·F W Wiegel
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Abstract

The authors determine the time-dependent ligand current into a spherical cell that is covered with a large number of age-dependent receptors. These receptors can be in either of two states: active (i.e., available for ligand binding) or inactive. An active receptor turns inactive upon binding a ligand, and it can reappear as active at some later time. The transition inactive----active is treated as a probabilistic process. The ligand distribution around the cell is determined analytically in terms of this distribution at the cell surface. A set of nonlinear integral equations is derived for the distribution at the cell surface, which is solved numerically. In this way the time-dependent ligand current into the cell as well as the average active receptor population at the cell surface are determined.

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Binding SitesCell MembraneCellular SenescenceChemoreceptor CellsMathematicsModels, BiologicalJournal Article

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BibTeXRIS

B J Geurts, F W Wiegel. 1990. Chemoreception by a cell with age-dependent receptor binding sites.. https://doi.org/10.1016/0025-5564(90)90122-f

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