Cognate interactions between helper T cells and B cells.

R J Noelle; E C Snow

doi:10.1016/0167-5699(90)90142-v

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Cognate interactions between helper T cells and B cells.

R J Noelle·E C Snow

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Abstract

The mechanism by which mammals produce an antibody response after exposure to antigen has intrigued biologists for over a hundred years. Here, Randolph Noelle and Charles Snow review some of the experimental findings since the early 1970s that have advanced understanding of the mechanisms operating during B-cell activation by thymus-dependent (TD) antigens. They also propose a model for B-cell activation that emphasizes the critical role played by direct cellular interactions between B cells and helper T(TH) cells and seek to place into perspective the role played by the membrane immunoglobulin (mlg) receptor in cognate responses.

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Animals Antigens, Surface B-Lymphocytes Histocompatibility Antigens Class II Lymphocyte Activation Models, Biological T-Lymphocytes, Helper-Inducer Journal Article Research Support, U.S. Gov't, P.H.S.Review

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R J Noelle, E C Snow. 1990. Cognate interactions between helper T cells and B cells.. https://doi.org/10.1016/0167-5699(90)90142-v

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