Hematoporphyrin diethers--V. Plasma protein binding and photosensitizing efficiency.

M Kongshaug; C Rimington; J F Evensen; Q Peng; J Moan

doi:10.1016/0020-711x(90)90110-o

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Hematoporphyrin diethers--V. Plasma protein binding and photosensitizing efficiency.

M Kongshaug·C Rimington·J F Evensen·Q Peng·J Moan

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Abstract

1. Binding of added hematoporphyrin (HP) ethers to human plasma proteins and lipoproteins has been investigated by ultracentrifugation. 2. The binding to low density lipoproteins (LDL) has been discussed in terms of photosensitized tumor growth delay of tumors and HPLC-retention time, i.e. degree of polarity. 3. The LDL-binding data show a uniform relationship to sensitizing efficiency and degree of polarity, the only exception being HP-diamyl ether. No such uniform relationship exists for less related dyes, such as HP, tetraphenylporphyrin tetrasulfonate and HP-dimethyl ether.

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Animals Blood Proteins Dihematoporphyrin Ether Hematoporphyrin Photoradiation Hematoporphyrins Humans Lipoproteins Lipoproteins, LDL Mammary Neoplasms, Experimental Radiation-Sensitizing Agents Serum Albumin Ultracentrifugation Comparative Study Journal Article Research Support, Non-U.S. Gov't

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M Kongshaug, C Rimington, J F Evensen, Q Peng, J Moan. 1990. Hematoporphyrin diethers--V. Plasma protein binding and photosensitizing efficiency.. https://doi.org/10.1016/0020-711x(90)90110-o

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