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PubMed · 2157897

Promoter evolution in BK virus: functional elements are created at sequence junctions.

R B Markowitz·S Tolbert·W S Dynan
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Abstract

The archetypal strain of BK virus directed very little early gene expression compared with rearranged laboratory strains of the virus. One laboratory strain that was analyzed in detail contained newly created AP-1 binding enhancer modules spanning the junction between adjacent sequence repeats. Introduction of these sequences into the archetype activated the previously quiescent early promoter.

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BK VirusBase SequenceBiological EvolutionCell LineChloramphenicol O-AcetyltransferaseChromosome MappingDNA-Binding ProteinsEnhancer Elements, GeneticGenes, RegulatorGenes, ViralHumansMolecular Sequence DataPolyomavirusPromoter Regions, GeneticProto-Oncogene Proteins c-junRNA, MessengerTranscription FactorsTranscription, GeneticTransfectionJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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R B Markowitz, S Tolbert, W S Dynan. 1990. Promoter evolution in BK virus: functional elements are created at sequence junctions.. https://doi.org/10.1128/jvi.64.5.2411-2415.1990

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