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PubMed · 2163110

beta-Arrestin: a protein that regulates beta-adrenergic receptor function.

M J Lohse·J L Benovic·J Codina·M G Caron·R J Lefkowitz
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Abstract

Homologous or agonist-specific desensitization of beta-adrenergic receptors is thought to be mediated by a specific kinase, the beta-adrenergic receptor kinase (beta ARK). However, recent data suggest that a cofactor is required for this kinase to inhibit receptor function. The complementary DNA for such a cofactor was cloned and found to encode a 418-amino acid protein homologous to the retinal protein arrestin. The protein, termed beta-arrestin, was expressed and partially purified. It inhibited the signaling function of beta ARK-phosphorylated beta-adrenergic receptors by more than 75 percent, but not that of rhodopsin. It is proposed that beta-arrestin in concert with beta ARK effects homologous desensitization of beta-adrenergic receptors.

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Amino Acid SequenceAnimalsAntigensArrestinBlotting, NorthernChromatography, Ion ExchangeCloning, MolecularCyclic AMP-Dependent Protein KinasesDNAEye ProteinsGene Expression RegulationMolecular Sequence DataPhosphodiesterase InhibitorsPhosphorylationProtein KinasesRNA, MessengerReceptors, Adrenergic, betaTransfectionbeta-Adrenergic Receptor KinasesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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M J Lohse, J L Benovic, J Codina, M G Caron, R J Lefkowitz. 1990-06-22. beta-Arrestin: a protein that regulates beta-adrenergic receptor function.. https://doi.org/10.1126/science.2163110

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