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Receptor-mediated calcium entry.

T J Rink
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Abstract

Occupation of membrane receptors can evoke calcium signals by causing depolarisation and activating voltage-operated calcium channels, by triggering internal release, or by stimulating calcium influx processes not gated by membrane potential, receptor-mediated calcium entry, RCME. This brief review considers different possible coupling mechanisms and the proposal that entry can occur from external medium to intracellular store, by-passing the cytosol, and regulated by the state of filling of the store. Recent studies using Mn2+ as a probe for RCME are outlined, as are some new electrophysiologic measurements with human platelets and investigations of a novel blocker of RMCE, SK&F 96365.

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AnimalsCalciumCalcium ChannelsElectric ConductivityFluorescent DyesHumansReceptors, Cell SurfaceSignal TransductionJournal ArticleReview

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T J Rink. 1990-08-01. Receptor-mediated calcium entry.. https://doi.org/10.1016/0014-5793(90)81290-5

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