PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 2184691

Cell adhesion molecules.

E Garcia-Gonzalez·R A Swerlick·T J Lawley
View original source ↗Export metadata ↓

Abstract

Recently it has become recognized that cell adhesion is critical in many different cellular functions. The proteins involved in the cell-cell or cell-matrix interactions are known as cell adhesion molecules (CAMs). This article reviews some of the most important CAMs and emphasizes their importance in dermatology and in skin diseases.

Explore related subjects

Cell Adhesion MoleculesHumansSkin DiseasesJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

E Garcia-Gonzalez, R A Swerlick, T J Lawley. 1990. Cell adhesion molecules.. https://doi.org/10.1097/00000372-199004000-00011

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1992

Up-regulation of intercellular adhesion molecule 1 transcription by hepatitis B virus X protein.

Intercellular adhesion molecule 1 (ICAM-1), a counter-receptor for lymphocyte function-associated antigen 1 on T cells, is critically important to a wide variety of adhesion-dependent leukocyte functions, including antigen presentation and target cell lysis. ICAM-1 expression by hepatocytes is increased in areas of inflammation and necrosis during chronic hepatitis B. Whether induction of ICAM-1 is due to the effect of inflammatory cytokines or involves a direct effect of the hepatitis B virus (HBV) remains unknown. In the present study, transfection of the HBV genome into human hepatoma cell lines resulted in enhanced expression of ICAM-1 protein and RNA in the absence of inflammation. Results of subgenomic transfections indicated that the HBV X protein (pX) induced ICAM-1 expression. Nuclear run-on assays showed that pX induced the ICAM-1 gene by increasing its rate of transcription. Although both pX and interferon gamma induced transcription of ICAM-1, addition of interferon gamma to cells expressing pX did not show an additive or synergistic effect. These results indicate that pX can directly regulate expression of ICAM-1 and may participate in the immunopathogenesis of HBV infection.

Cell Adhesion Molecules↗
PubMed1992

Human placental cells transformed with temperature-sensitive simian virus 40 are immortalized and mimic the phenotype of invasive cytotrophoblasts at both permissive and nonpermissive temperatures.

Establishment of the human placenta is essential for subsequent development of the embryo. Previous studies from our laboratories have demonstrated that chorionic villus cytotrophoblast stem cells undergo a stepwise differentiation process in vivo that results in their ability to invade the uterine wall. This process can be mimicked by isolated primary first-trimester cytotrophoblasts in vitro. Efforts to study the regulation of this differentiation pathway have been hampered by the inability of the isolated cytotrophoblast to replicate in culture. We therefore performed experiments to determine the suitability of the temperature-sensitive simian virus 40-transformed cell line SPA 255-26 (SPA-26), derived from early-gestation cytotrophoblasts, for studying the cytotrophoblast differentiation pathway that results in uterine invasion. Our results show that this cell line exhibits many properties of differentiated early-gestation cytotrophoblasts at both permissive and nonpermissive temperature. These cells were invasive in vitro and expressed the repertoire of hormones, adhesion molecules, and proteinases characteristic of an advanced stage of cytotrophoblast differentiation in vivo. Thus, these cells should be useful in studying the regulation of the adhesive and invasive behavior of human cytotrophoblasts.

Cell Adhesion Molecules↗
PubMed1992

Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells.

Soluble forms of the adhesion molecules ICAM-1, VCAM-1 and E-selectin have been detected in supernatants from cytokine activated cultured endothelial cells. The release has been quantified using two site enzyme immunoassays. The molecular weights of the released molecules have been determined by immunoprecipitation and are consistent with the generation of soluble forms by cleavage at a site close to the point of membrane insertion.

Cell Adhesion Molecules↗