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PubMed · 2184722

Screening for hypercholesterolemia.

T A Pearson·S Bowlin·W R Sigmund
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Abstract

The detection of individuals with hypercholesterolemia has received world-wide support as a means of determining who would benefit from dietary and pharmacologic interventions. However, the clinician or public health practitioner should be aware of several issues that must be resolved before cholesterol screening can attain maximal impact. This review examines whether hypercholesterolemia is a condition worthy of screening programs and discusses the promises and pitfalls of individual and mass screening approaches.

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CholesterolHumansHypercholesterolemiaMass ScreeningPredictive Value of TestsRisk FactorsJournal ArticleReview

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BibTeXRIS

T A Pearson, S Bowlin, W R Sigmund. 1990. Screening for hypercholesterolemia.. https://doi.org/10.1146/annurev.me.41.020190.001141

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[Dyslipoproteinemia and metabolic syndrome. Effects of insulin resistance and hyperinsulinemia on lipid metabolism].

Insulin resistance and consecutive hyperinsulinemia in individuals with the metabolic syndrome are associated with dyslipidemia. This latter is characterised by hypertriglyceridemia and a diminishment of high-density lipoprotein (HDL) cholesterol in the plasma. In severe forms of insulin resistance, low density lipoprotein (LDL) cholesterol may also be elevated. Hypertriglyceridemia is due to an increase in the rate of synthesis of very low density lipoproteins (VLDL) in the liver, and a reduction in their breakdown by the lipoprotein lipase in non-hepatic tissue. Changes in VLDL metabolism are associated with a reduction in HDL concentrations. In addition, direct effects of insulin on the lipid metabolism have been described. Changes in lipid metabolism due to insulin resistance and hyperinsulinemia may be of significance for the atherosclerosis risk in patients with the metabolic syndrome.

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