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6 beta-Hydroxycortisol excretion in hypercortisolemic states.

E Voccia·P Saenger·R E Peterson·W Rauh·K Gottesdiener·L S Levine·M I New
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Abstract

Urinary 6beta-hydroxycortisol (6betaOHF) excretion was measured and compared with free cortisol and 17-hydroxycorticosteroid (17OH) excretion in normal children, patients with Cushing's syndrome or disease (CSD), and patients during cortisol therapy. Normal 6betaOHF excretion in children was 0.23 +/- 0.03 mg/m2/24 h (mean +/- SE). No sex difference was found. ACTH infusion (40 U/day for 5 days) and high dose cortisol altered the 6 betaOHF:17OH ratio so that it was indistinguishable from the ratio seen in CSD. The fact that both Cushing's disease and high dose cortisol therapy caused the same change in the 6 betaOHF:17OH ratio suggests that cortisol and not ACTH induced 6beta-hydroxylase in hypercortisolemic subjects. Since the 6betaOHF:17OH ratio in CSD patients was always well above the normal range, measurement of 6betaOHF excretion was a better and more rapid test for chronic hypercortisolemia than urinary 17OH or free cortisol. Thus, measurement of urinary 6betaOHF is suggested as a good diagnostic test for hypercortisolemic states.

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17-HydroxycorticosteroidsAdolescentAdrenocorticotropic HormoneAdultChildCushing SyndromeFemaleHumansHydrocortisoneMaleJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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E Voccia, P Saenger, R E Peterson, W Rauh, K Gottesdiener, L S Levine, M I New. 1979. 6 beta-Hydroxycortisol excretion in hypercortisolemic states.. https://doi.org/10.1210/jcem-48-3-467

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PubMed2006

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