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PubMed · 219266

Stress-induced cortisol release in hypothalamic hypoadrenalism.

A R Glass·C E Smith
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Abstract

A 52-year-old woman experienced hypoadrenalism (mean 8 AM plasma cortisol level, 3.7 microgram/dL) after hypothalamic surgery and radiotherapy for craniopharyngioma. Despite low plasma adrenocorticotropic hormone levels (less than 25 pg/mL), absent diurnal variation of the plasma cortisol level, and subnormal urinary 17-hydroxycorticosteroid response to metyrapone, she had normal plasma cortisol responses to insulin-induced hypoglycemia and to administration of vasopressin or synthetic adrenocorticotropic hormone. Stress-induced cortical release may be preserved despite notable abnormalities in regulation of cortisol secretion by diurnal and feedback-mediated mechanisms.

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17-HydroxycorticosteroidsAdrenal InsufficiencyAdrenocorticotropic HormoneCircadian RhythmCraniopharyngiomaFeedbackFemaleHumansHydrocortisoneHypothalamusMetyraponeMiddle AgedPituitary NeoplasmsPostoperative CareStress, PsychologicalCase ReportsJournal Article

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A R Glass, C E Smith. 1979-04-13. Stress-induced cortisol release in hypothalamic hypoadrenalism.. https://pubmed.ncbi.nlm.nih.gov/219266/

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