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Insulin secretion in Walker 256 tumor cachexia.

L C Fernandes·U F Machado·C R Nogueira·A R Carpinelli·R Curi
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Abstract

The effect of cachexia on insulin secretion was examined in adult male rats. Isolated islets of Langerhans from Walker 256 tumor-bearing rats secreted less insulin by glucose stimuli as compared with the control group; this was accompanied by significant change in 45Ca2+ outflow rate. Reduced insulin secretion to glucose stimuli in tumor-bearing rats probably led to low insulinemia (one-third). These findings indicate that reduced insulin secretion is probably an important factor for the development of cachexia in Walker 256 tumor-bearing rats.

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AnimalsCachexiaCalciumCarcinoma 256, WalkerGlucoseIn Vitro TechniquesInsulinInsulin SecretionIslets of LangerhansKineticsMaleRatsRats, Inbred StrainsReference ValuesJournal ArticleResearch Support, Non-U.S. Gov't

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L C Fernandes, U F Machado, C R Nogueira, A R Carpinelli, R Curi. 1990. Insulin secretion in Walker 256 tumor cachexia.. https://doi.org/10.1152/ajpendo.1990.258.6.e1033

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