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Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule.

Yujun Huang·Yunji Park·Yiran Wang-Zhu·Alexandre Larange·Ramon Arens·Iván Bernardo·Danyvid Olivares-Villagómez·Dietmar Herndler-Brandstetter·Ninan Abraham·Beatrix Grubeck-Loebenstein·Stephen P Schoenberger·Luc Van Kaer·Mitchell Kronenberg·Michael A Teitell·Hilde Cheroutre
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Abstract

The presence of immune memory at pathogen-entry sites is a prerequisite for protection. Nevertheless, the mechanisms that warrant immunity at peripheral interfaces are not understood. Here we show that the nonclassical major histocompatibility complex (MHC) class I molecule thymus leukemia antigen (TL), induced on dendritic cells interacting with CD8αα on activated CD8αβ(+) T cells, mediated affinity-based selection of memory precursor cells. Furthermore, constitutive expression of TL on epithelial cells led to continued selection of mature CD8αβ(+) memory T cells. The memory process driven by TL and CD8αα was essential for the generation of CD8αβ(+) memory T cells in the intestine and the accumulation of highly antigen-sensitive CD8αβ(+) memory T cells that form the first line of defense at the largest entry port for pathogens.

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AnimalsAntigensCD8 AntigensCell DifferentiationClonal Selection, Antigen-MediatedDendritic CellsImmunity, MucosalImmunologic MemoryListeriosisLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred C57BLMice, TransgenicPrecursor Cells, T-LymphoidT-LymphocytesTransgenesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov't

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Yujun Huang, Yunji Park, Yiran Wang-Zhu, Alexandre Larange, Ramon Arens, Iván Bernardo, Danyvid Olivares-Villagómez, Dietmar Herndler-Brandstetter, Ninan Abraham, Beatrix Grubeck-Loebenstein, Stephen P Schoenberger, Luc Van Kaer, Mitchell Kronenberg, Michael A Teitell, Hilde Cheroutre. 2011-10-02. Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule.. https://doi.org/10.1038/ni.2106

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