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PubMed · 2201693

Direct serum injection high-performance liquid chromatographic method for the simultaneous determination of phenobarbital, carbamazepine and phenytoin.

S J Rainbow·C M Dawson·T R Tickner
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Abstract

A method is described for the simultaneous measurement of serum levels of three antiepileptic drugs, phenobarbital, phenytoin and carbamazepine, by direct injection high-performance liquid chromatography on a 25-cm Pinkerton internal surface reversed-phase (ISRP) column. Several commonly available compounds were tested and found not to co-chromatograph with the three drugs of interest or the internal standard, 5-(p-methylphenyl)-5-phenylhydantoin. Results obtained on patients' samples with this method compared well with those from enzyme-multiplied immunoassay technique (EMIT).

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CarbamazepineChromatography, High Pressure LiquidEpilepsyHumansImmunoenzyme TechniquesPhenobarbitalPhenytoinComparative StudyJournal Article

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S J Rainbow, C M Dawson, T R Tickner. 1990-05-18. Direct serum injection high-performance liquid chromatographic method for the simultaneous determination of phenobarbital, carbamazepine and phenytoin.. https://doi.org/10.1016/s0378-4347(00)82122-2

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