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PubMed · 2212598

Hyperbaric oxygen as adjunctive therapy for osteomyelitis.

J T Mader·K R Adams·W R Wallace·J H Calhoun
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Abstract

Mechanistically, hyperbaric oxygen (HBO) appears useful for the treatment of osteomyelitis. HBO increases the oxygen tension in infected tissue, including bone. An adequate oxygen tension is necessary for oxygen-dependent killing of organisms by the polymorphonuclear leukocytes and for fibroblast activity leading to angiogenesis and wound healing. HBO has a direct bacteriocidal or bacteriostatic effect on anaerobic organisms. In addition, HBO augments the killing of Pseudomonas aeruginosa by the aminoglycoside--tobramycin. At the University of Texas Medical Branch at Galveston, adjunctive HBO is used for the Cierny Mader stage 3B and 4B osteomyelitis.

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J T Mader, K R Adams, W R Wallace, J H Calhoun. 1990. Hyperbaric oxygen as adjunctive therapy for osteomyelitis.. https://pubmed.ncbi.nlm.nih.gov/2212598/

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