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Decrease in serum receptor-reactive somatomedin in diabetes.

R C Baxter·A S Brown·J R Turtle
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Abstract

Somatomedin in rat serum has been measured by a sensitive radioreceptor assay using 125I-labelled human somatomedin and human placental membrane. In rats made diabetic with strepotzotocin, receptor-reactive somatomedin levels were decrease by up to 75%. The decrease followed the time course of increasing serum glucose and occurred to the same extent in rats aged between 4 and 40 weeks. Endogenous serum receptor-reactive somatomedin appeared exclusively in high molecular weight fractions on gel chromatography. In diabetes the decreased somatomedin was due to a fall in this high molecular weight activity, but was not accompanied by a fall in somatomedin binding protein. These results suggest a role for insulin in maintaining serum somatomedin levels.

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AnimalsBiological AssayBlood GlucoseDiabetes Mellitus, ExperimentalFemaleHumansKineticsPlacentaPregnancyRatsReceptors, Cell SurfaceSomatomedinsStreptozocinJournal Article

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R C Baxter, A S Brown, J R Turtle. 1979. Decrease in serum receptor-reactive somatomedin in diabetes.. https://doi.org/10.1055/s-0028-1092711

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