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PubMed · 221840

Electroconvulsive shock treatment decrease beta-adrenergic receptor sensitivity in rat brain.

G N Pandey·W J Heinze·B D Brown·J M Davis
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AlprenololAnimalsCerebral CortexDesipramineElectroshockMaleRatsReceptors, AdrenergicReceptors, Adrenergic, betaJournal Article

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G N Pandey, W J Heinze, B D Brown, J M Davis. 1979-07-19. Electroconvulsive shock treatment decrease beta-adrenergic receptor sensitivity in rat brain.. https://doi.org/10.1038/280234a0

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PubMed1979

Increased number of beta-adrenergic receptors in the hypertrophied myocardium.

Development of cardiac hypertrophy is associated with depletion of endogenous catecholamine stores and increased inotropic response to exogenous catecholamines. A biochemical basis for these changes is provided by the observation that the number of cardiac beta-adrenergic receptors - as reflected in specific [3H]dihydroalprenolol binding - is increased in hypertrophy without a change in the affinity of dihydroalprenolol for the binding sites or in the capacity of isoproterenol to displace dihydroalprenolol. This change in beta-receptor numbers may be an important adaptive mechanism for preserving the contractile performance of the hypertrophied myocardium.

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