Decrease of cyclic GMP in cerebellar cortex by intrastriatal (--)-sulpiride.

M G Corda; M Casu; G Biggio

doi:10.1016/0014-2999(79)90203-6

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Decrease of cyclic GMP in cerebellar cortex by intrastriatal (--)-sulpiride.

M G Corda·M Casu·G Biggio

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Abstract

Intraperitoneal administration of (--)-sulpiride (12 to 50 mg/kg) produced a dose-related decrease in cGMP content in cerebellar cortex, while the (+)-sulpiride (10 microgram), but not after intracerebellar injection. These findings support the contention that (--)-sulpiride modifies cerebellar cGMP levels through and action on striatal dopamine receptors.

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Animals Cerebellar Cortex Corpus Striatum Cyclic GMP Depression, Chemical Injections Male Rats Stereoisomerism Sulpiride Time Factors Journal Article

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M G Corda, M Casu, G Biggio. 1979-05-01. Decrease of cyclic GMP in cerebellar cortex by intrastriatal (--)-sulpiride.. https://doi.org/10.1016/0014-2999(79)90203-6

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