Partial hepatectomy and mediators of inflammation decrease the expression of liver alpha 2-HS glycoprotein gene in rats.

M Daveau; C Davrinche; N Djelassi; J Lemetayer; N Julen; M Hiron; P Arnaud; J P Lebreton

doi:10.1016/0014-5793(90)81055-s

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Partial hepatectomy and mediators of inflammation decrease the expression of liver alpha 2-HS glycoprotein gene in rats.

M Daveau·C Davrinche·N Djelassi·J Lemetayer·N Julen·M Hiron·P Arnaud·J P Lebreton

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Abstract

Liver mRNA levels of two acute phase reactant (APR) proteins, alpha 2-HS glycoprotein (a major negative APR) and alpha 1-acid glycoprotein (a major positive APR) were measured in male rats at different times after the administration of turpentine, of tumor necrosis factor, or following partial hepatectomy. In every case, a marked decrease in mRNA levels of alpha 2-HS glycoprotein was observed which reached a maximum at 24 h. A concomitant increase of alpha 1-acid glycoprotein mRNA levels was observed under the same conditions. These results indicate that the decreased levels of alpha 2-HS glycoprotein induced by the acute-phase response following inflammatory mediators and partial hepatectomy are due to a down-regulation of the gene expression of this protein in rat liver.

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Animals Blotting, Northern Fibronectins Gene Expression Genes Hepatectomy Inflammation Male RNA, Messenger Rats Rats, Inbred Strains Recombinant Proteins Tumor Necrosis Factor-alpha Turpentine Journal Article

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M Daveau, C Davrinche, N Djelassi, J Lemetayer, N Julen, M Hiron, P Arnaud, J P Lebreton. 1990-10-29. Partial hepatectomy and mediators of inflammation decrease the expression of liver alpha 2-HS glycoprotein gene in rats.. https://doi.org/10.1016/0014-5793(90)81055-s

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