Neuron simulations with SABER.

N T Carnevale; T B Woolf; G M Shepherd

doi:10.1016/0165-0270(90)90017-a

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Neuron simulations with SABER.

N T Carnevale·T B Woolf·G M Shepherd

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Abstract

Computational models can provide critical tests of hypotheses of neuronal function. These models are essential for dealing with the complications of time- and voltage-dependent (active) ionic conductances. Commercial circuit analysis programs have been useful tools for this work. We report our experience modelling biophysically realistic membrane properties with SABER (Analogy, Inc.), a new general purpose simulator. SABER allows construction of models with arbitrary membrane properties. This is a major advantage over similar programs (e.g. SPICE), which are limited to a predefined library of electronic components. The empirically determined equations that describe rate constants, ionic conductances, currents, and concentration shifts can be translated directly into model elements ('templates') written in C-like code. We describe the development of SABER models that simulate a synapse and an action potential.

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Action Potentials Animals Axons Computer Simulation Humans Models, Neurological Neural Conduction Neurons Synapses Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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N T Carnevale, T B Woolf, G M Shepherd. 1990. Neuron simulations with SABER.. https://doi.org/10.1016/0165-0270(90)90017-a

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