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Central changes in hypothyroid myopathy: a case report.

R M Evans·I Watanabe·P A Singer
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Abstract

A muscle biopsy from a patient with hypothyroid myopathy showed striking central changes. "Cores" were seen in most type 1 fibers with oxidative enzyme preparations. Electron microscopy of these areas revealed Z disc streaming, myofilament disruption, and absent mitochondria. The myopathy rapidly improved with thyroxine treatment. This biopsy is of interest, as numerous "cores" have not previously been reported in hypothyroid myopathy.

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HumansHypothyroidismMaleMiddle AgedMusclesMuscular DiseasesCase ReportsJournal Article

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R M Evans, I Watanabe, P A Singer. 1990. Central changes in hypothyroid myopathy: a case report.. https://doi.org/10.1002/mus.880131011

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