Cellular peptide composition governed by major histocompatibility complex class I molecules.

K Falk; O Rötzschke; H G Rammensee

doi:10.1038/348248a0

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Cellular peptide composition governed by major histocompatibility complex class I molecules.

K Falk·O Rötzschke·H G Rammensee

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Abstract

Major histocompatibility complex (MHC) class I molecules present peptides derived from cellular proteins to cytotoxic T lymphocytes (CTLs), which check these peptides for abnormal features. How such peptides arise in the cell is not known. Here we show that the MHC molecules themselves are substantially involved in determining which peptides occur intracellularly: normal mouse spleen cells identical at all genes but MHC class I express different patterns of peptides derived from cellular non-MHC proteins. We suggest several models to explain this influence of MHC class I molecules on cellular peptide composition.

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Animals Antigen-Presenting Cells Chromatography, High Pressure Liquid Female H-2 Antigens H-Y Antigen Histocompatibility Antigens Class I Humans Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Peptides Spleen T-Lymphocytes, Cytotoxic Journal Article Research Support, Non-U.S. Gov't

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K Falk, O Rötzschke, H G Rammensee. 1990-11-15. Cellular peptide composition governed by major histocompatibility complex class I molecules.. https://doi.org/10.1038/348248a0

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