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Nonsteroidal antiinflammatory agents. Part 20(3): Optically active thienyl-biphenylyl-hydroxypropionic acids.

L Varoli·S Burnelli·A Guarnieri·G Scapini·V Andrisano·M Fantuz
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Abstract

The optically active diastereometric erythro- and threo-3-thienyl-analogues 6a-d of 3-aryl-2-biphenylyl-3-hydroxy-propionic acids have been prepared. Some stereoisomers of 3-(3-thienyl)derivative 6b showed inhibition around 40% in the carrageenan-induced rat paw edema test.

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AnimalsAnti-Inflammatory Agents, Non-SteroidalCarrageenanChemical PhenomenaChemistryEdemaLactatesMagnetic Resonance SpectroscopyMaleRatsRats, Inbred StrainsStereoisomerismThiophenesJournal ArticleResearch Support, Non-U.S. Gov't

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L Varoli, S Burnelli, A Guarnieri, G Scapini, V Andrisano, M Fantuz. 1990. Nonsteroidal antiinflammatory agents. Part 20(3): Optically active thienyl-biphenylyl-hydroxypropionic acids.. https://pubmed.ncbi.nlm.nih.gov/2236191/

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