Protein kinase recognition sequence motifs.

B E Kemp; R B Pearson

doi:10.1016/0968-0004(90)90073-k

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Protein kinase recognition sequence motifs.

B E Kemp·R B Pearson

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Abstract

Protein kinases play a crucial role in the regulation of many cellular processes. They alter the functions of their target proteins by phosphorylating specific serine, threonine and tyrosine residues. Identification of phosphorylation site sequences and studies with corresponding model peptides have provided clues to how these important enzymes recognize their substrate proteins. This knowledge has made it possible to identify potential sites of phosphorylation in newly sequenced proteins as well as to construct specific model substrates and inhibitors.

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Amino Acid Sequence Animals Binding Sites Humans Molecular Sequence Data Phosphorylation Protein Kinases Substrate Specificity Journal Article Review

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B E Kemp, R B Pearson. 1990. Protein kinase recognition sequence motifs.. https://doi.org/10.1016/0968-0004(90)90073-k

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