[The equation for platelet aggregation rate].

P V Vrzheshch; V V Verkhusha; S D Varfolomeev

PubMed · 2245229

[The equation for platelet aggregation rate].

P V Vrzheshch·V V Verkhusha·S D Varfolomeev

Abstract

A platelet aggregation model in shear flow taking into account the kinetics of intercellular fibrinogen bond formation limited by aggregated platelets rotation time was considered. For this consideration the average duration of platelets interaction in flow with shear rate value G is shown to be pi/4G. One fibrinogen bond is sufficient to form a solid aggregate between two platelets. The equation for single platelets disappearance rate concerned with intercellular fibrinogen bond formation, stochastic character of bond distribution in collided platelets and hydrodynamically controlled interaction time was obtained. The Hill's approximation for the obtained aggregation rate dependences was suggested and appropriate constants were determined. The qualitative criterion of platelets aggregating systems behavior was introduced.

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P V Vrzheshch, V V Verkhusha, S D Varfolomeev. [The equation for platelet aggregation rate].. https://pubmed.ncbi.nlm.nih.gov/2245229/

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