Age-related decrease in the number of hemopoietic stem cells and progenitors in senescence accelerated mice.

H Izumi-Hisha; Y Ito; K Sugimoto; H Oshima; K J Mori

doi:10.1016/0047-6374(90)90117-x

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Age-related decrease in the number of hemopoietic stem cells and progenitors in senescence accelerated mice.

H Izumi-Hisha·Y Ito·K Sugimoto·H Oshima·K J Mori

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Abstract

Senescence accelerated mice (SAM-P) were used for the study of the possible aging of hemopoiesis. The number of peripheral leukocytes decreased significantly with age, whereas hematocrit showed only a slight decrease. Although the number of total nucleated cells in the bone marrow increased, the number of hemopoietic stem cells (CFU-S) as well as that of granulocyte-macrophage colony forming cells (GM-CFC) showed a decrease in old mice. A significant decrease in the number of GM-CFC was observed in the spleen of old SAM-P mice, whereas no decrease was found in the number of CFU-S. Such a profound reduction of the recruitment of GM-CFC from CFU-S in the spleen together with a reduction of bone marrow hemopoiesis may be responsible for the decrease in the number of peripheral leukocytes in the old mice. SAM-P mice could provide a good model for the study of the aging of hemopoietic system.

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Aging Animals Blood Cell Count Bone Marrow Cells Cell Count Colony-Forming Units Assay Hematopoietic Stem Cells Male Mice Mice, Inbred AKR Spleen Journal Article Research Support, Non-U.S. Gov't

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H Izumi-Hisha, Y Ito, K Sugimoto, H Oshima, K J Mori. 1990. Age-related decrease in the number of hemopoietic stem cells and progenitors in senescence accelerated mice.. https://doi.org/10.1016/0047-6374(90)90117-x

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