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PubMed · 2264022

Coagulation impact on chemotactic activity generation for polymorphonuclear leukocytes.

A Morin·M M Arvier·F Doutremepuich·C Vigneron
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Abstract

Chemotactic technique in agarose gel has exposed the attractive properties of human alpha thrombin with respect to human polymorphonuclear leukocytes. The observed chemotaxis is maximal between 1.4.10-5 M and 1.6.10-5 M but extends from 2.8.10-6 M to 2.2.10-5 M. Human prothrombin, in an identical concentration zone as that studied for thrombin shows no chemotactic activity on the polymorphonuclear leukocytes. During coagulation the formed alpha thrombin attracts the polymorphonuclear leukocytes to it's formation site.

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Chemotactic FactorsChemotaxis, LeukocyteHumansNeutrophilsProthrombinThrombinJournal Article

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A Morin, M M Arvier, F Doutremepuich, C Vigneron. 1990-09-15. Coagulation impact on chemotactic activity generation for polymorphonuclear leukocytes.. https://doi.org/10.1016/0049-3848(90)90121-r

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