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PubMed · 2268358

Superactive insulins.

G T Burke·S Q Hu·N Ohta·G P Schwartz·L Zong·P G Katsoyannis
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Abstract

The substitution of aspartic acid for the naturally-occurring histidine residue in position B10 in human insulin results in an insulin analogue which displays an in vitro potency 4- to 5-fold greater than the parent compound. This substitution has been introduced into six insulin analogues which, before modification, display potencies ranging from less than 0.01-fold to 3-fold relative to natural insulin. In each case, the resulting aspartic acid-substituted analogue is substantially more potent than the parent compound. Thus, it is now possible to prepare "tailor-made" insulins with enhanced potency.

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Aspartic AcidHistidineHumansInsulinReceptor, InsulinJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

G T Burke, S Q Hu, N Ohta, G P Schwartz, L Zong, P G Katsoyannis. 1990-12-31. Superactive insulins.. https://doi.org/10.1016/s0006-291x(05)80882-4

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