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Interleukin-3.

G Wagemaker·H Burger·F C van Gils·R W van Leen·J J Wielenga
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Abstract

Interleukin-3 (IL-3) is a hemopoietic growth factor involved in the survival, proliferation and differentiation of multipotent hemopoietic cells. In five mammalian species, including man, the gene encoding IL-3 has been isolated and expressed to yield the mature recombinant proteins. The human IL-3 gene encodes a protein of 133 amino acids with two conserved cysteine residues and 2 potential N-linked glycosylation sites; human native IL-3 has not been characterized. Comparison of the IL-3 genes revealed a more rapid evolutionary divergence than has been observed for other hemopoietic growth factors, and, hence, a more pronounced species specificity of the functional proteins was found. In agreement with its stimulatory action on immature multipotent cells, the in vivo actions of homologous recombinant IL-3 in nonhuman primates include a highly increased production of blood cells along the neutrophilic, eosinophilic and basophilic granulocyte as well as the monocyte, red cell and platelet lineages.

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AnimalsHumansInterleukin-3PrimatesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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G Wagemaker, H Burger, F C van Gils, R W van Leen, J J Wielenga. 1990. Interleukin-3.. https://doi.org/10.1007/bf02170083

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