Methotrexate binding to human plasma proteins.

L Skibińska; C Ramlau; J Załuski; B Olejniczak

PubMed · 2274472

Methotrexate binding to human plasma proteins.

L Skibińska·C Ramlau·J Załuski·B Olejniczak

Abstract

The percentage of methotrexate (MTX) binding to plasma protein was 50.4 +/- 1.9 in healthy subject, and 32.3 +/- 3.6 in patients with cancer (breast carcinoma in most cases). Drugs used in combination with MTX in therapy (vincristine, vinblastine, cyclophosphamide, 5-fluorouracil, prednisone) depress the MTX binding to albumins. MTX binds to two kinds of albumins binding sites, with different binding constants: K1 = 8.88 mM-1 and K2 = 1.76 mM-1.

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Antineoplastic Combined Chemotherapy Protocols Blood Proteins Humans Kinetics Methotrexate Neoplasms Protein Binding Serum Albumin Journal Article Research Support, Non-U.S. Gov't

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L Skibińska, C Ramlau, J Załuski, B Olejniczak. Methotrexate binding to human plasma proteins.. https://pubmed.ncbi.nlm.nih.gov/2274472/

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