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PubMed · 2281177

[Changes in lymphocyte subsets after radiotherapy].

M Busetto·A Padoan·R Polico·M Antonello·G Turcato·O Nascimben·G Conte
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Abstract

Radiation therapy seems to induce depletion of lymphocytes, which are very important cells for immunity response. The lymphocyte phenotype was studied in 41 non-pretreated patients with normal immunological parameters who received postoperative radiation therapy for breast, mediastinal or pelvic cancer with at least 50 Gy/25 fractions. The functional immunological assessment was analyzed by Multiskin test (Merieux) too. The lymphocyte phenotype was determined on whole-blood lysate employing an Ortho double-fluorescence cytofluorimeter. All patients, after radiation treatment, exhibited decrement in absolute and percent lymphocyte subpopulations; the Multiskin test demonstrated simultaneous change in skin-test response. The results are highly significant (p 2-tailed area less than 0.0001) for absolute cells count and skin-delayed response test, but percent variations are not significant when verified by t-test.

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HumansLymphocyte DepletionLymphocyte SubsetsNeoplasmsPilot ProjectsRadiotherapyEnglish AbstractJournal Article

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M Busetto, A Padoan, R Polico, M Antonello, G Turcato, O Nascimben, G Conte. 1990. [Changes in lymphocyte subsets after radiotherapy].. https://pubmed.ncbi.nlm.nih.gov/2281177/

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