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PubMed · 2282688

Polymorphonuclear elastase in neonatal sepsis.

T Tsaka·K R Herkner
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Abstract

Quantitative analysis of polymorphonuclear elastase was carried out in 135 newborn infants during the first 28 days of life. In 15 neonates with septicaemia, significantly increased PMN-elastase activity (range 75 to 700 micrograms/l: P less than 0.0001) was observed at the time of recognition of infection. Cut-off level 65 micrograms/l. Normalisation of the elastase activities was observed only under real recovery of the patients. It is concluded that plasma elastase determination serves as a sensitive indicator of systemic infection in neonatology, and as a good parameter for monitoring the course of the disease, because PMN-elastase correlates with the clinical condition of the patient.

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Clinical Enzyme TestsFemaleHumansInfant, NewbornInfant, Premature, DiseasesMaleNeutrophilsPancreatic ElastasePredictive Value of TestsReproducibility of ResultsSepsisJournal Article

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BibTeXRIS

T Tsaka, K R Herkner. 1990-12-14. Polymorphonuclear elastase in neonatal sepsis.. https://doi.org/10.1016/0009-8981(90)90241-j

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